Hematuria

Hematuria
Classification and external resources
Microscopic hematuria
ICD-10	N02., R31.
ICD-9	599.7, 791.2
DiseasesDB	19635
eMedicine	ped/951
MeSH	D006417

In medicine, hematuria, or haematuria, is the presence of red blood cells (erythrocytes) in the urine. It may be idiopathic and/or benign, or it can be a sign that there is a kidney stone or a tumor in the urinary tract (kidneys, ureters, urinary bladder, prostate, and urethra), ranging from trivial to lethal. If white blood cells are found in addition to red blood cells, then it is a signal of urinary tract infection.

Occasionally "hemoglobinuria" is used synonymously, although more precisely it refers only to hemoglobin in the urine.

Types

Red discolouration of the urine can have various causes:

• Red blood cells
  • Microscopic hematuria (small amounts of blood, can be seen only on urinalysis or light microscopy)
  • Macroscopic hematuria (or "frank" or "gross") hematuria
• Hemoglobin (only the red pigment, not the red blood cells)
• Other pigments
  • Myoglobin in myoglobinuria
  • Porphyrins in porphyria
  • Betanin, after eating beets
  • Drugs such as Rifampicin and Phenazopyridine

Analysis

Hematuria seen directly in a urine sample.

A patient will be asked a number of questions:

• Have you passed any blood clots?
• Has a kidney stone been passed (noise in toilet bowl)?
• Is the red colour mixed in completely, or does the colour change during an episode of urination?
• Does it occur only after getting up?
• Have you recently had a sore throat?

Diagnosis

Often, the diagnosis is made on the basis of the medical history and some blood tests—especially in young people in whom the risk of malignancy is negligible and the symptoms are generally self-limited.

Ultrasound investigation of the renal tract is often used to distinguish between various sources of bleeding. X-rays can be used to identify kidney stones, although CT scanning is more precise.

In older patients, cystoscopy with biopsy of suspected lesions is often employed to investigate for bladder cancer.

If combined with pain, it may be loin pain hematuria syndrome.^[1]

Per AUA (American Urologic Association) guidelines,^[2] the following should be performed for high risk patients with significant microhematuria (greater than three red blood cells per high powered field):

1. Upper tract imaging of which a CT urogram is the gold standard
2. Urine cytology
3. Cystoscopy

Causes

The most common reason for hematuria in a man 50 years of age or older is Benign prostatic hyperplasia (BPH; enlarged prostate).^[3]

The most common causes in people younger than 40 years are kidney stones or ureter stones.^[4]

The most common causes of hematuria/haematuria are:

• Medications, for example, quinine, rifampin, phenytoin^[5]
• Prostate infection or inflammation (prostatitis)^[5]
• Trauma (e.g., a blow to the kidneys)
• Tumors and/or cancer in the urinary system,^[5] for example bladder cancer
• Urinary tract infection with viruses,^[5] other sexually transmitted diseases (particularly in women)^[5] or some bacterial species including strains of EPEC and Staphylococcus saprophyticus

Viral infections of the urinary tract and , particularly in women

• Kidney diseases^[5]

Other possible causes of hematuria include:

• Benign familial hematuria
• Urinary Schistosomiasis (caused by Schistosoma haematobium) - a major cause for hematuria in many African and Middle-Eastern countries;
• IgA nephropathy ("Berger's disease") - occurs during viral infections in predisposed patients;
• Renal cell carcinoma - occasionally presents with bleeding;
• Paroxysmal nocturnal hemoglobinuria - a rare disease where hemoglobin of hemolysed cells is passed into the urine.

• Sickle cell trait can precipitate large amounts of red blood cell discharge, but only a small number of individuals endure this problem
• Arteriovenous malformation of the kidney (rare, but may impress like renal cell carcinoma on scans as both are highly vascular)
• Nephritic syndrome (a condition associated with post-streptococcal and rapidly progressing glomerulonephritis).
• Fibrinoid necrosis of the Glomeruli (as a result of malignant hypertension)
• Bladder vescile varices may rarely develop secondary to obstruction of the inferior vena cava.^[6]
• Allergy may rarely cause episodic gross hematuria in children.^[7]
• Left renal vein hypertension, also called "nutcracker phenomenon" or "nutcracker syndrome," is a rare vascular abnormality responsible for gross hematuria.^[8]
• Ureteral Pelvic Junction Obstruction (UPJ) is a rare condition beginning from birth in which the ureter is blocked between the kidney and bladder. This condition may cause blood in the urine.^[9]
• March hematuria - Very prolonged exercise, such as long-distance horseback riding and bicycle riding.^[10]

References